A highly demanding process for ADCs

What happens when an antibody is linked to a cytotoxic compound? You get an antibody-drug conjugate (ADC), which is commonly used in cancer treatments. ADCs work by coupling an anticancer drug to an antibody that specifically targets a certain antigen on the target tumor. The drug then acts on tumor cells to kill or disable them.

The process for manufacturing antibody drug conjugates typically involves the use of solvents such as N, N -dimethylacetamide (DMA), N, N ‑dimethylformamide (DMF), dimethyl sulfoxide (DMSO), or propylene glycol (PG) to dissolve the drug so that it can link – become conjugated – to the protein.

501, 2021
  • Fusion Welding in action

Fusion Welding for Fluoropolymer Assemblies

Fusion Welding with Fluoropolymers: Building Stronger Bonds Typically, the weakest parts (and most likely failure points) of any custom assembly are the welded joints. But with fusion welding, that’s not the case. Savillex has developed proprietary, non-contact fusion welding equipment and techniques that can be used to build stronger, high-purity

1812, 2020

Custom Part Design for New Semiconductor Gas Filters

Custom Parts for Semiconductor Gas Filtration Gas filtration is a critical step in the semiconductor manufacturing process. If gasses like ammonia and boron trichloride aren’t properly filtered, contaminants can cause defects to wafers during fabrication. Porvair is one of the world’s largest players in a semiconductor gas filtration market that

912, 2020
  • Savillex employee removing bottle

Rapid Freeze-Thaw Performance of Single-Use PFA Bottles

Can Single-Use Containers Survive Dramatic Temperature Changes? The most demanding processes that utilize single-use containers – like bulk drug substance (BDS) storage – often involve rapid and vary large shifts in temperature. So called “flash freezing” is commonly used for vaccines and blood products due to concerns over protein

112, 2020
  • Savillex Integration Services

Introducing Integration Services for Single-Use Systems

Can You Offer Custom, Single-Use Assembly That’s Easily Scalable? If you’ve made the switch to single-use technology, one of the biggest limitations you may have already encountered is a lack of true, open-architecture style product customization. You also may have felt the frustration of sourcing parts from multiple providers and

2610, 2020
  • PFA bottles for bulk drug substance

Ready-To-Use Innovations Eliminate BDS Hassles

PFA the gold standard for BDS When it comes to critical BDS (bulk drug substance) storage, PFA bottle and vials have become the gold standard. That’s because performance and purity aren’t a “nice-to-have” in BDS – they’re an expectation. In critical applications – such as storing vaccines or blood products

2110, 2020
  • Manufacturing facility team of scientists wearing sterile protective coverall

Benefits of PFA vs PTFE for the Semiconductor Manufacturing Process

What are the Key Differences Between PTFE and PFA, Anyway? When you think about fluoropolymer early adopters, who springs to mind? If you answered, “the semiconductor industry,” you’d be spot-on. The semiconductor industry was one of the first to widely use fluoropolymers. Why? For starters, fluoropolymers’ inertness, resistance to high