Savillex employee packaging bottlesLipid nanoparticles can be tough to transport

Lipids, typically in the form of lipid nanoparticles (LNPs), are a key component of the delivery systems for messenger RNA (mRNA) vaccines. This includes recently approved vaccines from Pfizer and Moderna currently being used in the fight against COVID-19.

LNPs deliver COVID-19’s spike protein mRNA directly to our cells, which then replicate the protein and cause our bodies to initiate an immune response to the virus. This helps protect us if we are infected with COVID-19.

Lipids, like glycerides, cholesterols and proteins, easily stick to surfaces (adsorb) when in a solution. This can be a serious problem that only worsens as the concentration of the lipid solution increases or as the particle size decreases. Lipids also have a long history of sticking to the insides of bottles and other storage containers, reducing yield when the lipids are emptied out.

Recent developments in LNP manufacturing now require the lipid to be dissolved in an organic solvent (typically 90% ethanol). However, using these solvents increases the risk of contaminants being leached from commonly used polymer containers.

Fluoropolymers help lipids avoid sticky storage situations

Fluoropolymer containers – like Purillex® ready-to-use bottles and vials from Savillex – are ideal for storing lipids, glycerides, cholesterols and proteins (and other sticky solutions) because of their non-stick inner surfaces.

Purillex® bottles are manufactured from PFA and ETFE fluoropolymers, which have high purity and extremely low leachables – even with aggressive solvents. In addition – Purillex® bottles are supplied pre-sterilized and ready-to-use.

To recap – the benefits of Purillex® bottles and vials for LNP transport and storage include:

  • Non-stick surface
  • Inert to virtually every reagent chemistry
  • Low extractables and leachables
  • Single material in contact with product
  • High integrity seal, no cap liner needed
  • Available clean, pre-sterilized and ready-to-use
  • Sizes from 3 mL to 2000 mL

Have a challenging application in mind that could benefit from our fluoropolymer bottles and vials? Get detailed technical info and explore the product lineup online.

For additional information, or to obtain pricing, please give us a call today.